The structure of a NEMO construct engineered for screening reveals novel determinants of inhibition
Amy E. Kennedy, Adam H. Barczewski, Christina R. Arnoldy, Joseph Pepper Pennington, Kelly A. Tiernan, Maria Beatriz Hidalgo, Caroline C. Reilly, Tanyawan Wongsri, Michael J. Ragusa, Gevorg Grigoryan, Dale F. Mierke, Maria Pellegrini
The paper describes engineered NEMO constructs that enable structural analysis of the NEMO/IKK interaction, revealing a novel ligand binding motif and informing inhibitor design.
Structure · Jan 1, 2024Peer-reviewedBiophysics