Michael J. Ragusa

The Z-shaped N-terminal Domain of Atg11 Coordinates Atg9 Recruitment in Selective Autophagy

This study identifies the mechanism by which Atg11 recruits Atg9 in yeast selective autophagy through structural and biochemical analysis.

Atg23 Interacts With Both the N- and C-termini of Atg9 Via a Hydrophobic Binding Pocket

This study determines the crystal structure of Atg23 and identifies hydrophobic interactions between Atg23 and both N- and C-terminal regions of Atg9.

Membrane composition-dependent patterning of Rho and F-actin in an artificial cell cortex

This study shows that membrane composition regulates self-organized cortical patterning of active Rho and F-actin in an artificial cell cortex.

The LC3-interacting region of NBR1 is a protein interaction hub enabling optimal flux

This study identifies overlapping SLiMs in NBR1 that mediate interactions with multiple autophagy receptors, revealing cooperative binding mechanisms and the regulatory role of phosphorylation.

The structure of a NEMO construct engineered for screening reveals novel determinants of inhibition

The paper describes engineered NEMO constructs that enable structural analysis of the NEMO/IKK interaction, revealing a novel ligand binding motif and informing inhibitor design.