Regulation of cancer epigenomes with a histone-binding synthetic transcription factor
Karmella A. Haynes, David B. Nyer, Daniel Vargas, Caroline Hom
This paper describes the genome-wide behavior of a synthetic transcription factor, PcTF, showing it bridges histone modifications with transcription initiation and activates tumor suppressor genes in cancer cells.
bioRxiv · Sep 1, 2016Synthetic Biology