Human CTC1 primarily functions in telomere maintenance/protection and promotes CHK1 phosphorylation in response to global replication stress
Stephanie M. Ackerson, Caroline I. Gable, Jason A. Stewart
This study shows that CTC1 is essential for telomere protection and that its deletion leads to G2 arrest and apoptosis, but not genome-wide replication defects or DNA damage.
Cell Cycle · Dec 3, 2020Peer-reviewedMolecular Biology