Somatic mutation but not aneuploidy differentiates lung cancer in never-smokers and smokers.
Sitapriya Moorthi, Amy L. Paguirigan, Minjeong Ko, Mary B. Pettinger, Anna C. H. Hoge, Anwesha Nag, Neil A. Patel, Feinan Wu, Cassie L. Sather, Matthew Fitzgibbon, Aaron R. Thorner, Garnet L. Anderson, Gavin Ha, Alice H. Berger
The paper compares somatic mutations and aneuploidy in lung adenocarcinomas from never-smokers and smokers, finding that mutations, not copy number changes, distinguish the two groups.
bioRxiv · Jan 5, 2023 · PreprintGenomics