Anwesha Nag

Fusion-driven oncogenic programs shape the immune landscape in translocation renal cell carcinoma

This study identifies fusion-driven oncogenic programs in translocation renal cell carcinoma (tRCC) that shape an immunosuppressive tumor microenvironment, explaining its reduced immunotherapy response.

Metastatic Osteosarcoma is Characterized by Loss of Osteoblastic Lineage Fidelity

This study identifies a loss of osteoblastic lineage fidelity in metastatic osteosarcoma through single-nucleus RNA sequencing, linking it to disease progression and potential therapeutic targets.

Epigenetic dysregulation of metabolic programs mediates liposarcoma cell plasticity

This study identifies epigenetic dysregulation of metabolic programs in liposarcoma, linking IGF1 loss and PPARG2 deficiency to dedifferentiation and proposing IGF1R-targeted therapy.

Evaluation of single-cell RNA profiling technologies using FFPE, fresh, and frozen ccRCC tumor specimens

The paper compares single-cell RNA profiling technologies using different sample types to assess their performance in tumor specimens.

Somatic mutation but not aneuploidy differentiates lung cancer in never-smokers and smokers.

The paper compares somatic mutations and aneuploidy in lung adenocarcinomas from never-smokers and smokers, finding that mutations, not copy number changes, distinguish the two groups.

DNA methylation is a key mechanism for maintaining monoallelic expression on autosomes

The paper identifies DNA methylation as a key mechanism for maintaining monoallelic expression on autosomes and reveals its tunable control of allele-specific expression.