Clinicopathologic Dissociation: Robust Lafora Body Accumulation in Malin KO Mice Without Observable Changes in Home-cage Behavior
Vaishnav Krishnan, Jun Wu, Arindam Ghosh Mazumder, Jessica L. Kamen, Catharina Schirmer, Nandani Adhyapak, John Samuel Bass, Sam Lee, Atul Maheshwari, Gemma Molinaro, Jay R. Gibson, Kimberly M. Huber, Berge Arakel Minassian
This study shows that malin-deficient mice accumulate Lafora bodies without observable neurobehavioral decline, suggesting a delay between LB accumulation and clinical symptoms.
The Journal of Comparative Neurology · Jul 1, 2024Peer-reviewedNeuroscience