Kimberly M. Huber

This study identifies GAA accumulation in gliomas as a driver of neuronal activity and tumor growth, linking cancer metabolism to neuroscience through GABAA receptor activation.

The paper identifies CEND1 as a regulator of activity-dependent glucose metabolism by facilitating mitochondrial ATP channeling to hexokinase I.

This study shows that reduced CB1 receptor function in GABAergic neurons of FXS model mice rescues cortical hyperexcitability and sensory-driven synchrony deficits.

This study shows that malin-deficient mice accumulate Lafora bodies without observable neurobehavioral decline, suggesting a delay between LB accumulation and clinical symptoms.

This study shows that inhibiting WNK kinases improves learning and memory in mice by enhancing hippocampal glucose uptake and insulin signaling.

This study identifies female-specific neocortical circuit dysfunction in a mouse model of autism linked to mGluR5 and estrogen receptor α, leading to hyperexcitability and behavioral deficits.

This study shows that postsynaptic FMRP is required for maturation of callosal synapses in mice, with sensory experience modulating synaptic strength.

This study shows that FMRP loss reduces ribosome stalling on specific mRNAs, leading to altered H3K36me3 marks and alternative splicing of autism-related genes.