Viral overexpression of human alpha-synuclein in mouse substantia nigra dopamine neurons results in hyperdopaminergia but no neurodegeneration
Sofia Ines Garcia Moreno, Fabian Limani, Iina Ludwig, Catherine Gilbert, Christian Pifl, Thomas S. Hnasko, Thomas Steinkellner
This study overexpresses human alpha-synuclein in mouse dopamine neurons and finds increased dopamine levels and activity without neurodegeneration.
Experimental Neurology · Sep 15, 2024Peer-reviewedNeuroscience