Mapping the evolution of T cell states during response and resistance to adoptive cellular therapy
Pavan Bachireddy, Elham Azizi, Cassandra Burdziak, Vinhkhang N Nguyen, Christina Ennis, Zi-Ning Choo, Shuqiang Li, Kenneth J Livak, Donna S Neuberg, Robert J Soiffer, Jerome Ritz, Edwin P Alyea, Dana Pe'er, Catherine J Wu
The paper maps T cell state evolution during response and resistance to adoptive cellular therapy using single-cell transcriptomics and machine learning, identifying key exhausted subsets and their origins.
bioRxiv · Jul 8, 2020Cancer Biology