Pavan Bachireddy

Molecular and cellular dynamics of measurable residual disease progression in myelodysplastic syndromes

This study identifies molecular features of MRD progression in MDS using single-cell multi-omic profiling, revealing dynamic evolutionary processes and immunoevasive mechanisms.

ASXL1 truncating mutations drive leukemic resistance to T cell attack

This study identifies ASXL1 truncating mutations as a driver of leukemic resistance to T cell attack and proposes EZH2 inhibition as a therapeutic strategy to overcome this resistance.

Coordinated Immune Cell Networks in the Bone Marrow Microenvironment Define the Graft versus Leukemia Response with Adoptive Cellular Therapy

The paper analyzes single-cell data from bone marrow samples to identify immune cell interactions that predict response to adoptive cellular therapy in myeloid leukemia.

Mapping the evolution of T cell states during response and resistance to adoptive cellular therapy

The paper maps T cell state evolution during response and resistance to adoptive cellular therapy using single-cell transcriptomics and machine learning, identifying key exhausted subsets and their origins.