Jerome Ritz

This paper introduces APC-ms, a platform that expands rare tumor-antigen-specific T cells from peripheral blood, achieving higher enrichment and functional properties compared to conventional methods.

This paper develops LIME, a bacterial platform that engagers T and NK cells to target tumors, showing enhanced cytotoxicity and immune response in preclinical models.

The paper identifies recipient stem-cell persistence and T-cell dysregulation as predictors of relapse after HSCT in AML/MDS by analyzing single-cell RNA and TCR sequencing data.

This study identifies ASXL1 truncating mutations as a driver of leukemic resistance to T cell attack and proposes EZH2 inhibition as a therapeutic strategy to overcome this resistance.

The paper analyzes single-cell data from bone marrow samples to identify immune cell interactions that predict response to adoptive cellular therapy in myeloid leukemia.

This study uses plasma cell-free RNA profiles to monitor immune dynamics and predict graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation.

The paper maps T cell state evolution during response and resistance to adoptive cellular therapy using single-cell transcriptomics and machine learning, identifying key exhausted subsets and their origins.

This study uses cell-free DNA methylation profiling in plasma to identify organ-specific injury and predict COVID-19 severity in hospitalized patients.

This study demonstrates that cell-free DNA analysis can detect multiple post-transplant complications in HCT recipients through methylation, metagenomic, and genomic profiling.