Combination of Cas9 and adeno-associated vectors (AAVs) enables efficient in vivo knockdown of precise miRNAs in the rodent brain
David Roura‐Martínez, Natalia Popa, Florence Jaouen, Cynthia Rombaut, Catherine Lépolard, Dipankar Bachar, Ana Borges, Maxime Cazorla, Maxime Villet, Sébastien Moréno, Hélène Marie, Eduardo Gascon
This study develops a method to efficiently knock down specific miRNAs in the rodent brain using Cas9 and AAV vectors, demonstrating functional effects on neuronal migration and AMPA receptor activity.
bioRxiv · Mar 26, 2025 · PreprintNeuroscience