Maxime Cazorla

This study develops a method to efficiently knock down specific miRNAs in the rodent brain using Cas9 and AAV vectors, demonstrating functional effects on neuronal migration and AMPA receptor activity.

The paper uses a brain-on-chip model to show genetic perturbations alter network topology in corticostriatal circuits, leading to new convergent nodes in hyperexcitable neural networks.

This study shows that Alix is required for activity-dependent bulk endocytosis at brain synapses, and its absence reduces seizure severity in mice.