Extrafollicular B cell responses are associated with autoreactivity against the slit diaphragm in idiopathic podocytopathies
Tho-Alfakar Al-Aubodah, Simon Leclerc, Lamine Aoudjit, Zhiyang Liu, Ratna Samanta, Cherry Mammen, Allison B. Dart, Anne‐Laure Lapeyraque, Catherine Morgan, Mallory L. Downie, Kunimasa Yan, Satoka Mori, Susan M. Samuel, Ciriaco A. Piccirillo, Tomoko Takano
This study identifies extrafollicular B cell responses as a key driver of autoreactivity against slit diaphragm proteins in idiopathic podocytopathies, with distinct patterns in children and adults.
bioRxiv · Sep 6, 2025 · PreprintImmunology