A double-hit in vivo model of GBA1 viral microRNA-mediated downregulation and human alpha-synuclein overexpression demonstrates nigrostriatal degeneration
Alexia Polissidis, Effrosyni Koronaiou, Georgia B. Nikolopoulou, Catherine Viel, Maria Nikatou, Marios Bogiongko, S. Pablo Sardi, Maria Xilouri, Kostas Vekrellis, Leonidas Stefanis
This study creates a double-hit mouse model combining GBA1 downregulation and alpha-synuclein overexpression to show synergistic nigrostriatal neurodegeneration in Parkinson's disease.
Neurobiology of Disease · Jan 4, 2022Peer-reviewedNeuroscience