Maria Xilouri

This study evaluates PHP.eB AAVs for reducing alpha-synuclein burden in a mouse model of alpha-synucleinopathies, showing reduced pathology and motor deficits.

The paper investigates the role of oligodendroglial-derived extracellular vesicles in spreading pathology in MSA-like models, showing they carry pathological Synuclein and TPPP/p25 and induce disease in animal models.

The paper identifies a kinase inhibitor, BX795, that rescues pathological phenotypes in a patient-derived Parkinson's disease model through proteomic analysis and high-content screening.

This study creates a double-hit mouse model combining GBA1 downregulation and alpha-synuclein overexpression to show synergistic nigrostriatal neurodegeneration in Parkinson's disease.

This study compares α-synuclein fibril structures from Parkinson's disease and Multiple System Atrophy patients, showing differences in their quaternary arrangement and effects on oligodendroglial cells.