Proton motive force mediated efflux mismatch drives gentamycin-novobiocin collateral sensitivity in Pseudomonas aeruginosa
Hafij Al Mahmud, Md Siddiqur Rahman, Erika Ortiz Ruiz, Alex R. Luecke, Amanda M. V. Brown, Catherine Wakeman
This study identifies a PMF-efflux mismatch mechanism causing collateral sensitivity between gentamycin and novobiocin in Pseudomonas aeruginosa through genomic and transcriptomic analysis.
bioRxiv · May 5, 2026 · PreprintMicrobiology