Network Modeling Predicts How DYRK1A Inhibition Promotes Cardiomyocyte Cycling after Ischemic/Reperfusion Injury
Bryce Cameron Murillo, Alexander Young, Kaitlyn L. Wintruba, Alexander J Eichert, Klara Siejda, Dennon Hoernig, Leigh A. Bradley, Bryana N. Harris, Catherine Zhao, MIchelle Wu, Emmanuel Deau, Mattias F. Lindberg, Laurent Meijer, Jeffrey J. Saucerman, Matthew J. Wolf
The paper develops a computational network model predicting DYRK1A inhibition promotes cardiomyocyte cycling after ischemic/reperfusion injury, validated through experiments in neonatal rat cardiomyocytes.
JCI Insight · Sep 17, 2026Peer-reviewedPharmacology & Toxicology