Author

Kaitlyn L. Wintruba

University of VirginiaORCID 0009-0009-6522-9643Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pharmacology & Toxicology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Organism:rat· 1

Frequent Co-Authors

Jeffrey J. SaucermaniD· 2 shared Aitor AguirreiD· 1 shared Aleksandra S. KostinaiD· 1 shared Alexander J Eichert· 1 shared Alexander Young· 1 shared Bryana N. Harris· 1 shared Bryce Cameron MurilloiD· 1 shared Catherine Zhao· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersSystems Biology

Jeffrey J. SaucermanORCID

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2 papers

Recent·Most cited

Network-enabled drug repurposing identifies lithium to promote cardiomyocyte proliferation

Kaitlyn L. Wintruba, Sunil Kumar Verma, Irfan S. Kathiriya, Aleksandra S. Kostina, Aitor Aguirre, Muge N. Kuyumcu‐Martinez, Jeffrey J. Saucerman

This paper uses a computational framework to identify FDA-approved drugs that can promote cardiomyocyte proliferation, finding lithium as a potential therapeutic but highlighting congenital risks.

bioRxiv · Oct 16, 2026 · PreprintSystems Biology

Network Modeling Predicts How DYRK1A Inhibition Promotes Cardiomyocyte Cycling after Ischemic/Reperfusion Injury

Bryce Cameron Murillo, Alexander Young, Kaitlyn L. Wintruba, Alexander J Eichert, Klara Siejda, Dennon Hoernig, Leigh A. Bradley, Bryana N. Harris, Catherine Zhao, MIchelle Wu, Emmanuel Deau, Mattias F. Lindberg, Laurent Meijer, Jeffrey J. Saucerman, Matthew J. Wolf

The paper develops a computational network model predicting DYRK1A inhibition promotes cardiomyocyte cycling after ischemic/reperfusion injury, validated through experiments in neonatal rat cardiomyocytes.

JCI Insight · Sep 17, 2026Peer-reviewedPharmacology & Toxicology