Landscape-scale navigation unlocks antibody CDR structural logic for AI-guided rescue and therapeutic optimization
Changju Chun, Byeong-Kwon Sohn, Heesoo Ki, Ji Hye Jo, Hyoung-Tae An, Jinseo Park, Jiyu Lee, Sooyeon Choi, J H Choi, Hyeyoung Cho, Seong Beom Lee, Booyoung Yu, Chae Young Lee, Ji Eun Kim, Yu-jin Ban, , Tae‐Young Yoon
The paper uses high-throughput antibody variant analysis and AI models to optimize antibody productivity by navigating fitness landscapes and identifying structurally compatible CDR variants.
bioRxiv · Apr 23, 2026 · PreprintBioengineering