Author
Seoul National UniversityORCID 0000-0002-5184-7725Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Changju Chun, Byeong-Kwon Sohn, Heesoo Ki…·Tae‐Young Yoon
The paper uses high-throughput antibody variant analysis and AI models to optimize antibody productivity by navigating fitness landscapes and identifying structurally compatible CDR variants.
Sang Ah Kim, Jesper Levring, Jue Chen, Tae‐Young Yoon
This study uses single-molecule magnetic tweezers to analyze CFTR folding defects and shows pharmacological correctors reshape the folding energy landscape by catalyzing transitions.
Changju Chun, Byeong-Kwon Sohn, Ji Hye Jo…·Tae‐Young Yoon
The paper introduces a method to map antibody-antigen interactions using SPID platform to enhance affinity prediction and optimize antibody design.
The paper uses single-molecule co-immunoprecipitation to profile BCL2 interactions with BH3-only proteins, revealing how mutations affect ABT-199 resistance through quantitative PPI data.
Changju Chun, Ja Min Byun, Minkwon Cha…·Tae‐Young Yoon
The paper predicts BH3 mimetic efficacy by analyzing PPI complexes in AML, identifying BCL2-BAX and BCLxL-BAK as key mediators of drug response and resistance.
Chanwoo Lee, Dante Lepore, Mary Munson, Tae‐Young Yoon
This study shows the exocyst complex facilitates multiple steps in SNARE complex assembly and vesicle fusion using purified yeast exocyst in reconstituted systems.