Spatiotemporal AI modeling of gene regulation and variant effects in the developing human brain
Yun Hao, Christopher Y. Park, Chandra T Theesfeld, Olga G. Troyanskaya
This paper introduces Seal, an AI framework that models gene regulation and variant effects in the developing human brain across multiple regions, cell types, and stages, identifying regulatory mechanisms linked to neuropsychiatric diseases.
bioRxiv · Oct 11, 2026 · PreprintGenomics