Christopher Y. Park

This paper introduces Seal, an AI framework that models gene regulation and variant effects in the developing human brain across multiple regions, cell types, and stages, identifying regulatory mechanisms linked to neuropsychiatric diseases.

Mixture modeling of 239 phenotype features in 5,392 SPARK autistic children defines four replicable classes carrying distinct common and rare variant signatures and developmental gene-timing patterns.

The paper identifies RBP target site dysregulation as a major contributor to psychiatric disorder risk, revealing new insights into disease heritability and providing a resource for further research.

The paper develops a mouse model to identify FMRP mRNA targets in specific neurons, revealing that FMRP binds to a ranked subset of long genes related to Fragile X phenotypes.

The paper uses AGO CLIP to identify miRNA-target interactions in the brain after ischemic stroke, revealing miR-29 family members lose target regulation, leading to rapid proteomic changes in glutamate homeostasis.

This study identifies ZFP36 RNA-binding proteins as regulators of T-cell activation and anti-viral immunity, showing they restrain T-cell expansion and effector functions.