Stabilization of the trimeric pre-fusion structures of influenza H1 and H9 hemagglutinins by mutations in the stem helices
Ga Young Lee, Yun Geun Kim, Shin Hc, Chang Jun Lee, Jie‐Oh Lee
This study stabilizes the pre-fusion trimeric structures of influenza H1 and H9 hemagglutinins through stem helix mutations, enhancing thermal stability and immunogenicity.
bioRxiv · Aug 27, 2025 · PreprintBiophysics