Jie‐Oh Lee

This paper develops an mRNA-based therapy combining IFNγ and FasICD to induce tumor cell death and immune activation, showing significant tumor regression in mice.

This study determines the cryo-EM structures of CD28 and CTLA-4 interacting with B7-family ligands on membranes, revealing how membrane geometry and ligand binding affect immune checkpoint signaling.

This study stabilizes the pre-fusion trimeric structures of influenza H1 and H9 hemagglutinins through stem helix mutations, enhancing thermal stability and immunogenicity.

The paper reports cryo-EM structures of TNF and BAFF ligand-receptor-adaptor complexes clustered on lipid membranes, showing that ordered clustering is essential for receptor activation.