Dissecting the respective roles of microbiota and host genetics in the susceptibility of Card9-/- mice to colitis
Camille Danne, Bruno Lamas, Aonghus Lavelle, Marie‐Laure Michel, Grégory Da Costa, Hang‐Phuong Pham, Antoine Lefèvre, Chantal Bridonneau, Marius Bredon, Julien Planchais, Marjolène Straube, Patrick Emond, Philippe Langella, Harry Sokol
This study investigates how Card9 genotype and microbiota influence colitis susceptibility in Card9-/- mice, showing both direct and microbiota-dependent roles in IL-22 production and recovery.
bioRxiv · Jan 3, 2023 · PreprintGenetics