Harry Sokol

Exome sequencing directly implicates 68 genes in inflammatory bowel disease

This study uses exome and genome sequencing to identify 68 genes directly associated with inflammatory bowel disease, providing clearer genetic insights and therapeutic targets.

Faecalibacterium prausnitzii induces an anti-inflammatory response and a metabolic reprogramming in human monocytes

This study shows that Faecalibacterium prausnitzii induces IL-10 production and metabolic changes in human monocytes, with anti-inflammatory effects and mitochondrial dependence.

Taxonomic-free metagenome GWAS to identify gut microbiome functions influencing host phenotypes

The paper develops a taxonomy-free GWAS method using k-mers to analyze gut microbiome associations with host phenotypes, identifying significant links to seven traits in a cohort of healthy participants.

Decoding E. coli's Gut Survival Strategies: A CRISPRi Approach Across Diets, Inflammatory Environment and Strains

This study uses CRISPRi to identify genetic factors affecting E. coli adaptation across diets, inflammation, and strains in a mouse model.

Dietary tryptophan enhances aryl hydrocarbon receptor activation and reduces colitis through microbial metabolism

This study shows dietary tryptophan improves AhR activation and reduces colitis by enhancing microbial tryptophan metabolism in preclinical models.

Differential translocation of bacteriophages across the intestinal barrier in health and Crohn's disease

The paper investigates phage translocation across the intestinal barrier in health and Crohn's disease, finding increased phage presence in blood samples from CD patients.

Reduced intestinal GLP-1+ cell numbers are associated with an inflammation-related epithelial metabolic signature

The paper shows reduced GLP-1+ cell numbers in inflamed intestinal tissues of mice and CD patients, linked to an inflammatory metabolic signature affecting epithelial differentiation.

Integrative metagenomics and metabolomics reveal age-associated gut microbiota and metabolite alterations in experimental COVID-19

This study uses metagenomics and metabolomics to show age-related gut microbiota and metabolite changes in hamsters with experimental COVID-19, linking them to disease severity and recovery.

Inhibition of IL-22-producing cells by Sutterella sp. bacteria

This study identifies Sutterella sp. as a commensal pathobiont that inhibits IL-22 production and AhR activity, offering insights into gut inflammation regulation.

The human blood harbors a phageome which differs in Crohn's disease

The paper studies the blood virome in healthy individuals and Crohn's disease patients, finding distinct viral communities associated with the disease.

A multivariate outcome test of covariance

The paper introduces MANOCCA, a method to test the effect of predictors on the covariance matrix of multivariate outcomes, showing it outperforms existing methods in simulations and identifies significant associations in real data.

Dissecting the respective roles of microbiota and host genetics in the susceptibility of Card9-/- mice to colitis

This study investigates how Card9 genotype and microbiota influence colitis susceptibility in Card9-/- mice, showing both direct and microbiota-dependent roles in IL-22 production and recovery.

Age-associated gut microbiota impairs hippocampus-dependent memory in a vagus-dependent manner

This study shows that age-related gut microbiota impair hippocampus-dependent memory via a vagus nerve-dependent mechanism, and suggests pharmacogenetic vagus stimulation as a potential therapeutic strategy.