The NEDD8 cycle controlled by NEDP1 upon DNA damage is a regulatory module of the HSP70 ATPase activity
Aymeric Bailly, Aurélien Perrin, Marina Serrano‐Maciá, Chantal M. Maghames, Orsolya Leidecker, Hélène Trauchessec, ML Martinez-Chantar, Anton Gartner, Dimitris P. Xirodimas
The paper shows that NEDP1 regulates the NEDD8 cycle upon DNA damage, modulating HSP70 ATPase activity to promote apoptosis and identifies this as relevant in hepatocellular carcinoma.
bioRxiv · Mar 22, 2019 · PreprintMolecular Biology