Enhanced Complement Expression in the Tumor Microenvironment Following Neoadjuvant Therapy: Implications for Immunomodulation and Survival in Pancreatic Ductal Adenocarcinoma
Xiaofei Zhang, Ruoxin Lan, Yongjun Liu, Venu Gopal Pillarisetty, Danting Li, Chaohui L Zhao, Suparna A. Sarkar, Weiguo Liu, Iman T. Hanna, Mala R. Gupta, Cristina H Hajdu, Jonathan Melamed, Jessica L. Widmer, John Allendorf, Yaozhong Liu
This study shows neoadjuvant therapy in PDAC increases complement gene expression in the tumor microenvironment, linked to better survival and reduced immune exhaustion.
bioRxiv · Oct 26, 2023 · PreprintCancer Biology