Relaxed 3D genome conformation facilitates the pluripotent to totipotent state transition in embryonic stem cells
Jiali Yu, Yezhang Zhu, Jiahui Gu, Chaoran Xue, Long Zhang, Jiekai Chen, Li Shen
The paper investigates how relaxed 3D genome conformation during the pluripotent-to-totipotent transition in mouse ESCs facilitates totipotency acquisition through changes in chromatin structure and enhancer dynamics.
bioRxiv · Nov 4, 2020 · PreprintMolecular Biology