Li Shen

Parthenogenote-Derived Brain Unveils the Critical Role of Paternal Genome in Neural Development

This study uses a novel cell replacement strategy to show that the paternal genome is critical for neural development through Dlk1-mediated regulation of Notch signaling.

Transcriptomic and spatial GABAergic neuron subtypes in zona incerta mediate distinct innate behaviors

The paper identifies two distinct GABAergic neuron subtypes in the zona incerta that mediate different innate behaviors through specific projections.

Multimodal single-cell analyses reveal molecular markers of neuronal senescence in human drug-resistant epilepsy

CXXC-finger protein 1 associates with FOXP3 to stabilize homeostasis and suppressive functions of regulatory T cells

This study shows that CXXC1 interacts with FOXP3 to regulate Treg cell function and epigenetic stability, essential for immune homeostasis and preventing inflammation.

scART: recognizing cell clusters and constructing trajectory from single-cell epigenomic data

scART is a tool for analyzing scATAC-seq data that identifies cell clusters and constructs developmental trajectories, demonstrating effectiveness in mouse embryonic forebrain data.

Genome-wide decoupling of H2Aub and H3K27me3 in early mouse development

The paper identifies genome-wide decoupling of H2Aub and H3K27me3 in early mouse development, showing their distinct and independent functions.

Relaxed 3D genome conformation facilitates the pluripotent to totipotent state transition in embryonic stem cells

The paper investigates how relaxed 3D genome conformation during the pluripotent-to-totipotent transition in mouse ESCs facilitates totipotency acquisition through changes in chromatin structure and enhancer dynamics.