The phosphate exporter XPR1 regulates a gasdermin D-independent mature IL-1β secretion pathway in LPS-stimulated human monocytic cells
Nathalie Rémy, Charlotte Six, Sandrine Tury, Emile VAN SCHAFTINGEN, Jean‐Luc Battini, Sophie Lucas, Pierre G. Coulie, Tiphanie Gomard
This study identifies XPR1 as a regulator of GSDMD-independent IL-1β secretion in human monocytic cells, linking it to phosphate export and revealing a novel pathway for cytokine release.
bioRxiv · Dec 25, 2025 · PreprintImmunology