Jean‐Luc Battini

The phosphate exporter XPR1 regulates a gasdermin D-independent mature IL-1β secretion pathway in LPS-stimulated human monocytic cells

This study identifies XPR1 as a regulator of GSDMD-independent IL-1β secretion in human monocytic cells, linking it to phosphate export and revealing a novel pathway for cytokine release.

Structural basis of phosphate export by human XPR1

This study determines the cryo-EM structure of XPR1, identifies Pi-binding sites, and shows how PP-IPs regulate its activity through conformational changes.

The human plasma amino acids balance favours HIV replication in primary CD4 T lymphocytes

The study shows that amino acid balance, not energy metabolism, promotes HIV-1 replication in primary CD4 T cells under near-physiological conditions.