Partition Coefficients Reveal Changes in Properties of Low-Contrast Biomolecular Condensates
Kaarthik Varma, Dana Matthias, Chase B. Shapiro, Sullivan Bailey-Darland, Takumi Matsuzawa, Charlotta Lorenz, Teagan Bate, Stephen J. Thornton, Senthilkumar Duraivel, Robert W. Style, James P. Sethna, Eric R. Dufresne
The paper shows that adding small molecules to biomolecular condensates reduces their partition coefficients to physiological levels, revealing changes in their material properties and behavior.
bioRxiv · Feb 23, 2026 · PreprintBiophysics