POLQ variants with aberrant DNA polymerase activity protect against UV-induced cell death.
Steven E. Weicksel, Corey Thomas, Ethan Hall, Kylie Davis, Chase Michalczik, Sreerupa Ray, Jamie B. Towle-Weicksel
This study examines POLQ variants in melanoma tumors, showing they have reduced DNA repair efficiency but can protect against UV-induced cell death.
bioRxiv · Nov 26, 2025 · PreprintBiochemistry