A Dominant-Negative HIF-1 Isoform Protects Neuronal Development by Buffering the Response to Hypoxia in C. elegans
Amirsaeed Sabeti Aghabozorgi, Chelsey Torres, Kate Andrea Locsin, Carlos Egydio de Carvalho
The paper shows that C. elegans neurons use a dominant-negative HIF-1 isoform to buffer hypoxia responses during development, preventing miswiring defects.
bioRxiv · Aug 21, 2026 · PreprintDevelopmental Biology