Two Spag6 genes control sperm formation and male fertility in mice
Yunhao Liu, Weidong Li, Tao Li, Cheng Zheng, Changmin Niu, Alain Schmitt, Yi Tian Yap, Mohammad Abdulghani, Shuiqiao Yuan, Christian Melander, Jerome F. Strauss, Aminata Touré, Ling Zhang, Zhibing Zhang
This study identifies two Spag6 genes in mice and shows their distinct roles in sperm formation and male fertility, with SPAG6 being critical for fertility despite normal phenotype in single knockout mice.
bioRxiv · Jul 18, 2025 · PreprintDevelopmental Biology