Changmin Niu

This study shows that COPS5 is essential for Sertoli cell function and male fertility in mice, as its loss causes infertility through disrupted cell polarity, blood-testis barrier integrity, and gap junction communication.

This study identifies two Spag6 genes in mice and shows their distinct roles in sperm formation and male fertility, with SPAG6 being critical for fertility despite normal phenotype in single knockout mice.