Brain-derived exosomal hemoglobin transfer contributes to neuronal mitochondrial homeostasis under hypoxia
Zhengming Tian, Li Yu-ning, Feiyang Jin, Zirui Xu, Yakun Gu, Mengyuan Guo, Qianqian Shao, Yingxia Liu, Hanjiang Luo, Yue Wang, Suyu Zhang, Chenlu Yang, Xin Liu, Xunming Ji, Jia Liu
This study identifies exosomal hemoglobin transfer from non-neuronal cells to neurons under hypoxia as a mechanism to maintain mitochondrial homeostasis and protect against neurological injury.
eLife · Oct 2, 2024Peer-reviewedCell Biology