Author

Zirui Xu

Capital Medical University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Qianqian ShaoiD· 3 shared Yakun GuiD· 3 shared Zhengming TianiD· 3 shared Feiyang JiniD· 2 shared Jia LiuiD· 2 shared Mengyuan GuoiD· 2 shared Xunming JiiD· 2 shared Yingxia LiuiD· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersNeuroscience

Qianqian ShaoORCID

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3 papers

Recent·Most cited

Ser129 Phosphorylation Paradox: Non-phosphorylated α-Synuclein Drives Parkinson' s Disease-like Pathogenesis in Vivo

Zhengming Tian, Zirui Xu, Mengyuan Guo, Haoyi Fang, Hui Yang, Qianqian Shao, Dongjun Wang, Feiyang Jin, Yakun Gu, Guiyou Liu, Rehana K. Leak, Jun Chen, Jia Liu

This study shows that non-phosphorylated α-synuclein drives Parkinson's disease-like pathogenesis in mice, contradicting the traditional view that phosphorylated α-synuclein is pathogenic.

bioRxiv · Dec 23, 2025 · PreprintNeuroscience

HIF-1α/STOML2 mediated PINK1-dependent mitophagy activation against hypoxia-induced neuronal injury

Yuning Li, Mengyuan Guo, Zhengming Tian, Qianqian Shao, Yingxia Liu, Yakun Gu, Zirui Xu, Feiyang Jin, Xunming Ji, Jia Liu

This study identifies a PINK1-dependent mitophagy pathway activated by hypoxia through HIF-1α/STOML2 axis, which protects neurons and suggests intermittent hypoxia as a therapeutic strategy.

bioRxiv · Apr 16, 2025 · PreprintNeuroscience

Brain-derived exosomal hemoglobin transfer contributes to neuronal mitochondrial homeostasis under hypoxia

Zhengming Tian, Li Yu-ning, Feiyang Jin, Zirui Xu, Yakun Gu, Mengyuan Guo, Qianqian Shao, Yingxia Liu, Hanjiang Luo, Yue Wang, Suyu Zhang, Chenlu Yang, Xin Liu, Xunming Ji, Jia Liu

This study identifies exosomal hemoglobin transfer from non-neuronal cells to neurons under hypoxia as a mechanism to maintain mitochondrial homeostasis and protect against neurological injury.

eLife · Oct 2, 2024Peer-reviewedCell Biology