ACTN3 genotype influences skeletal muscle mass regulation and response to dexamethasone
Jane T. Seto, Kelly N. Roeszler, Lyra R. Meehan, Harrison D. Wood, Chrystal F. Tiong, Lucinda Bek, Cheryl Lee, Paul Gregorevic, Peter J. Houweling, Kathryn N. North
This study shows that ACTN3 genotype affects skeletal muscle mass regulation and response to dexamethasone, with -actinin-3 deficiency reducing atrophy signaling and protecting against muscle wasting in female mice.
Minerva Access (University of Melbourne) · Jan 1, 2020Peer-reviewedGenetics