Harrison D. Wood

This study shows that alpha-actinin-3 deficiency improves cold tolerance through enhanced mitochondrial function and reduced muscle mass loss during acute cold exposure.

This study shows that ACTN3 genotype affects androgen response in skeletal muscle by altering AR expression and pathways related to muscle homeostasis.

The paper shows that absence of α-actinin-3 in humans improves cold resilience through changes in skeletal muscle thermogenesis and myosin heavy chain composition.

This study shows that ACTN3 genotype affects skeletal muscle mass regulation and response to dexamethasone, with -actinin-3 deficiency reducing atrophy signaling and protecting against muscle wasting in female mice.