Paul Gregorevic

Changing the Fate of Dystrophin-Deficient Myoblasts via Hetero ligand Nanoclusters on Biomaterial Surface: Effects of Integrin-Syndecan or Dystroglycan Crosstalk

This paper demonstrates that nanoclusters of integrin-, syndecan-, and dystroglycan-binding peptides on biomaterial surfaces enhance myoblast adhesion, proliferation, and differentiation in dystrophin-deficient cells.

Site-specific quantification of the in vivo UFMylome reveals myosin modification in ALS

The paper quantifies UFMylation sites in mouse tissues and ALS patient biopsies, finding increased myosin UFMylation in ALS.

The Rho GTPase Rac1 mediates exercise training adaptations

This study identifies Rac1 as a key regulator of exercise training adaptations by showing its role in protein synthesis, glycogen resynthesis, and running capacity in mice and human muscle.

Proteome-wide systems genetics identifies UFMylation as a regulator of skeletal muscle function

The paper identifies UFMylation as a negative regulator of skeletal muscle function through proteome-wide systems genetics in mice and validates it in a disease model.

Detailed metabolic phenotyping of four tissue specific Cas9 transgenic mouse lines

This study demonstrates that long-term tissue-specific Cas9 expression in mice does not cause detrimental health effects or metabolic changes, supporting its use for gene-specific studies.

ACTN3 genotype influences skeletal muscle mass regulation and response to dexamethasone

This study shows that ACTN3 genotype affects skeletal muscle mass regulation and response to dexamethasone, with -actinin-3 deficiency reducing atrophy signaling and protecting against muscle wasting in female mice.