Disrupting miR-466l-3p and HuR Cooperation with Target Site Blockers Reveals a Therapeutic Strategy to Destabilize mRNA Transcripts
Vinod S. Ramgolam, Timur Olegovich Yarovinsky, Sarah Huntenburg, Cheryl M. Bergman, Nancy H. Ruddle, Jeffrey R. Bender
This paper identifies miR-466l-3p and HuR cooperation in stabilizing mRNAs and demonstrates that Target Site Blockers (TSBs) can disrupt this interaction to destabilize target transcripts and suppress cytokine production.
bioRxiv · Apr 1, 2026 · PreprintMolecular Biology