A conserved interaction between a C-terminal motif in Norovirus VPg and the HEAT-1 domain of eIF4G is essential for translation initiation
Eoin N Leen, Frédéric Sorgeloos, Samantha Correia, Yasmin Chaudhry, Fabien Cannac, Chiara pastore, Yingqi Xu, Stephen C Graham, Stephen J Matthews, Ian G Goodfellow, Stephen Curry
This study identifies a conserved C-terminal motif in norovirus VPg that binds to eIF4G HEAT-1 domain, essential for translation initiation and a potential antiviral target.
PLOS Pathogens · Jan 6, 2016Peer-reviewedMolecular Biology