Frédéric Sorgeloos

The leader proteins of Theiler's virus and Boone cardiovirus use a combination of Short Linear Motifs (SLiMs) to target RSK kinases to the nuclear pore complex.

This paper identifies a second SLiM in cardiovirus L proteins that enables RSK kinases to target the nuclear pore complex via RAE1 interaction.

A simple workflow to identify novel Small Linear Motif (SLiM)-mediated interactions with AlphaFold

This paper introduces a workflow using AlphaFold and MiniPAE to predict and validate novel Small Linear Motif (SLiM)-mediated protein interactions, demonstrating its effectiveness with RSK kinases.

The "DDVF" motif used by viral and bacterial proteins to hijack RSK kinases evolved as a mimic of a short linear motif (SLiM) found in proteins related to the RAS-ERK MAP kinase pathway.

The paper identifies human proteins that interact with RSK kinases via DDVF-like SLiMs, showing pathogens mimic these motifs to alter RAS-ERK MAPK pathway regulation.

Leaked genomic and mitochondrial DNA contribute to the host response to noroviruses in a STING-dependent manner

This study shows that the cGAS-STING pathway restricts noroviruses by detecting leaked genomic and mitochondrial DNA, leading to IFN responses.

A conserved interaction between a C-terminal motif in Norovirus VPg and the HEAT-1 domain of eIF4G is essential for translation initiation

This study identifies a conserved C-terminal motif in norovirus VPg that binds to eIF4G HEAT-1 domain, essential for translation initiation and a potential antiviral target.