Systemic-to-mucosal trafficking of memory B cells contributes to humoral immunity in the upper respiratory tract
Eva Piano Mortari, Mattia Laffranchi, Bianca Laura Cinicola, Chiara Sugoni, Sabina Barresi, Valentina Marcellini, Emanuele Agolini, Christian Albano, Gabriele Volpe, Marco Scarsella, Ezio Giorda, Alessandro Sparaci, Reparata Rosa Di Prinzio, Salvatore Zaffina, Concetta Quintarelli, , Rita Carsetti
The paper shows that systemic memory B cells traffic to mucosal sites in the upper respiratory tract, contributing to local immunity, and that antigen-specific B cells accumulate there only during local inflammation.
bioRxiv · Jul 15, 2026 · PreprintImmunology