Mattia Laffranchi

The paper shows that systemic memory B cells traffic to mucosal sites in the upper respiratory tract, contributing to local immunity, and that antigen-specific B cells accumulate there only during local inflammation.

This study shows CD300e deficiency worsens obesity-related metabolic dysfunction in mice and human cells, highlighting its role in adipose tissue macrophage metabolism and potential as a therapeutic target.

This study identifies CD300e as a driver of immunosuppressive tumor microenvironment in colorectal cancer by reprogramming macrophages to suppress T-cell function and promote tumor growth.