High dose IFN-β activates GAF to enhance expression of ISGF3 target genes in epithelial cells
Kensei Kishimoto, Catera L. Wilder, Justin Buchanan, Minh Nguyen, Chidera Okeke, Alexander Hoffmann, Quen J. Cheng
The paper shows that high-dose IFN-β activates both ISGF3 and GAF in epithelial cells, with GAF enhancing ISGF3 target gene expression through co-localization and chromosome looping.
Frontiers in Immunology · Apr 9, 2021Peer-reviewedMolecular Biology